In this study, we investigated changes in active layer thickness (ALT) and permafrost temperatures at different depths using data from permafrost monitoring network along the Qinghai-Xizang (Tibet) Railway since 2005. Among sites, average ALT is about 3.1 m with a range from about 1.1 m to 4.9 m. From 2006 through 2010, ALT has increased at a rate of about 6.3 cm a<sup>−1</sup>. The mean rising rate of permafrost temperature at the depth of 6.0 m is about 0.02 °C a<sup>−1</sup> estimated by linear regression using five years of data, and the mean rising rate of mean annual ground temperature (MAGT) at depth of zero amplitude is about 0.012 °C a<sup>−1</sup>. Changes for colder permafrost (MAGT < −1.0 °C) is greater than that for relatively warmer permafrost (MAGT > −1.0 °C). This is consistent with results observed in the Arctic and Subarctic.